An optimized single chain TCR scaffold relying on the assembly with the native CD3-complex prevents residual mispairing with endogenous TCRs in human T-cells

Immunotherapy of cancer envisions the adoptive transfer of T-cells genetically engineered with tumor-specific heterodimeric α/β T-cell receptors (TCRα/β). However, potential mispairing of introduced TCRα/β-chains with endogenous β/α-ones may evoke unpredictable autoimmune reactivities. A novel singl...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Knies, Diana, Klobuch, Sebastian, Xue, Shao-An, Birtel, Matthias, Echchannaoui, Hakim, Yildiz, Oezlem, Omokoko, Tana, Guillaume, Philippe, Romero, Pedro, Stauss, Hans, Sahin, Ugur, Herr, Wolfgang, Theobald, Matthias, Thomas, Simone, Voss, Ralf-Holger
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2016
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Research Paper: Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5008279/
https://ncbi.nlm.nih.gov/pubmed/27028870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8385
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