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Inhibition of Bcl-xL sensitizes cells to mitotic blockers, but not mitotic drivers

Cell fate in response to an aberrant mitosis is governed by two competing networks: the spindle assembly checkpoint (SAC) and the intrinsic apoptosis pathway. The mechanistic interplay between these two networks is obscured by functional redundancy and the ability of cells to die either in mitosis o...

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Bibliografske podrobnosti
izdano v:Open Biol
Main Authors: Bennett, Ailsa, Sloss, Olivia, Topham, Caroline, Nelson, Louisa, Tighe, Anthony, Taylor, Stephen S.
Format: Artigo
Jezik:Inglês
Izdano: The Royal Society 2016
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5008013/
https://ncbi.nlm.nih.gov/pubmed/27512141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsob.160134
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