The sclerostin-neutralizing antibody AbD09097 recognizes an epitope adjacent to sclerostin's binding site for the Wnt co-receptor LRP6

The glycoprotein sclerostin has been identified as a negative regulator of bone growth. It exerts its function by interacting with the Wnt co-receptor LRP5/6, blocks the binding of Wnt factors and thereby inhibits Wnt signalling. Neutralizing anti-sclerostin antibodies are able to restore Wnt activi...

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Detalhes bibliográficos
Publicado no:Open Biol
Main Authors: Boschert, V., Frisch, C., Back, J. W., van Pee, K., Weidauer, S. E., Muth, E.-M., Schmieder, P., Beerbaum, M., Knappik, A., Timmerman, P., Mueller, T. D.
Formato: Artigo
Idioma:Inglês
Publicado em: The Royal Society 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5008011/
https://ncbi.nlm.nih.gov/pubmed/27558933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsob.160120
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