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Liraglutide prevents and reverses monocrotaline-induced pulmonary arterial hypertension by suppressing ET-1 and enhancing eNOS/sGC/PKG pathways

Liraglutide, a glucagon-like peptide-1 receptor (GLP-1R) agonist, is widely used to treat diabetes. However, its effect on pulmonary arterial hypertension (PAH) is unknown. In this study, we investigated its effects on rats with monocrotaline (MCT)-induced PAH and mechanisms on rat pulmonary artery...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Sci Rep
Main Authors: Lee, Mei-Yueh, Tsai, Kun-Bow, Hsu, Jong-Hau, Shin, Shyi-Jang, Wu, Jiunn-Ren, Yeh, Jwu-Lai
פורמט: Artigo
שפה:Inglês
יצא לאור: Nature Publishing Group 2016
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC5007506/
https://ncbi.nlm.nih.gov/pubmed/27581840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep31788
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