Ethyl Pyruvate Combats Human Leukemia Cells but Spares Normal Blood Cells

Ethyl pyruvate, a known ROS scavenger and anti-inflammatory drug was found to combat leukemia cells. Tumor cell killing was achieved by concerted action of necrosis/apoptosis induction, ATP depletion, and inhibition of glycolytic and para-glycolytic enzymes. Ethyl lactate was less harmful to leukemi...

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Vydáno v:PLoS One
Hlavní autoři: Birkenmeier, Gerd, Hemdan, Nasr Y. A., Kurz, Susanne, Bigl, Marina, Pieroh, Philipp, Debebe, Tewodros, Buchold, Martin, Thieme, Rene, Wichmann, Gunnar, Dehghani, Faramarz
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2016
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5006986/
https://ncbi.nlm.nih.gov/pubmed/27579985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0161571
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