Effective antitumor therapy based on a novel antibody-drug conjugate targeting the Tn carbohydrate antigen

Antibody-drug conjugates (ADC), combining the specificity of tumor recognition by monoclonal antibodies (mAb) and the powerful cytotoxicity of anticancer drugs, are currently under growing interest and development. Here, we studied the potential of Chi-Tn, a mAb directed to a glyco-peptidic tumor-as...

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Bibliografiske detaljer
Udgivet i:Oncoimmunology
Main Authors: Sedlik, Christine, Heitzmann, Adèle, Viel, Sophie, Ait Sarkouh, Rafik, Batisse, Cornélie, Schmidt, Frédéric, De La Rochere, Philippe, Amzallag, Nathalie, Osinaga, Eduardo, Oppezzo, Pablo, Pritsch, Otto, Sastre-Garau, Xavier, Hubert, Pascale, Amigorena, Sebastian, Piaggio, Eliane
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2016
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5006918/
https://ncbi.nlm.nih.gov/pubmed/27622021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2016.1171434
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