Effective antitumor therapy based on a novel antibody-drug conjugate targeting the Tn carbohydrate antigen

Antibody-drug conjugates (ADC), combining the specificity of tumor recognition by monoclonal antibodies (mAb) and the powerful cytotoxicity of anticancer drugs, are currently under growing interest and development. Here, we studied the potential of Chi-Tn, a mAb directed to a glyco-peptidic tumor-as...

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Detalles Bibliográficos
Publicado en:Oncoimmunology
Main Authors: Sedlik, Christine, Heitzmann, Adèle, Viel, Sophie, Ait Sarkouh, Rafik, Batisse, Cornélie, Schmidt, Frédéric, De La Rochere, Philippe, Amzallag, Nathalie, Osinaga, Eduardo, Oppezzo, Pablo, Pritsch, Otto, Sastre-Garau, Xavier, Hubert, Pascale, Amigorena, Sebastian, Piaggio, Eliane
Formato: Artigo
Idioma:Inglês
Publicado: Taylor & Francis 2016
Assuntos:
Original Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5006918/
https://ncbi.nlm.nih.gov/pubmed/27622021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2016.1171434
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