Broad HIV-1 inhibition in vitro by vaccine-elicited CD8(+) T cells in African adults

We are developing a pan-clade HIV-1 T-cell vaccine HIVconsv, which could complement Env vaccines for prophylaxis and be a key to HIV cure. Our strategy focuses vaccine-elicited effector T-cells on functionally and structurally conserved regions (not full-length proteins and not only epitopes) of the...

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Pubblicato in:Mol Ther Methods Clin Dev
Autori principali: Mutua, Gaudensia, Farah, Bashir, Langat, Robert, Indangasi, Jackton, Ogola, Simon, Onsembe, Brian, Kopycinski, Jakub T, Hayes, Peter, Borthwick, Nicola J, Ashraf, Ambreen, Dally, Len, Barin, Burc, Tillander, Annika, Gilmour, Jill, De Bont, Jan, Crook, Alison, Hannaman, Drew, Cox, Josephine H, Anzala, Omu, Fast, Patricia E, Reilly, Marie, Chinyenze, Kundai, Jaoko, Walter, Hanke, Tomáš, HIV-CORE 004 study group, the
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5006719/
https://ncbi.nlm.nih.gov/pubmed/27617268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtm.2016.61
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