Metformin attenuates lung fibrosis development via NOX4 suppression

BACKGROUND: Accumulation of profibrotic myofibroblasts in fibroblastic foci (FF) is a crucial process for development of fibrosis during idiopathic pulmonary fibrosis (IPF) pathogenesis, and transforming growth factor (TGF)-β plays a key regulatory role in myofibroblast differentiation. Reactive oxy...

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Veröffentlicht in:Respir Res
Hauptverfasser: Sato, Nahoko, Takasaka, Naoki, Yoshida, Masahiro, Tsubouchi, Kazuya, Minagawa, Shunsuke, Araya, Jun, Saito, Nayuta, Fujita, Yu, Kurita, Yusuke, Kobayashi, Kenji, Ito, Saburo, Hara, Hiromichi, Kadota, Tsukasa, Yanagisawa, Haruhiko, Hashimoto, Mitsuo, Utsumi, Hirofumi, Wakui, Hiroshi, Kojima, Jun, Numata, Takanori, Kaneko, Yumi, Odaka, Makoto, Morikawa, Toshiaki, Nakayama, Katsutoshi, Kohrogi, Hirotsugu, Kuwano, Kazuyoshi
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2016
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5006432/
https://ncbi.nlm.nih.gov/pubmed/27576730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12931-016-0420-x
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