Phase 1 randomized controlled trial to evaluate the safety and immunogenicity of recombinant Pichia pastoris-expressed Plasmodium falciparum apical membrane antigen 1 (PfAMA1-FVO [25-545]) in healthy Malian adults in Bandiagara

BACKGROUND: The safety and immunogenicity of PfAMA1, adjuvanted with Alhydrogel(®) was assessed in malaria–experienced Malian adults. The malaria vaccine, PfAMA1-FVO [25-545] is a recombinant protein Pichia pastoris-expressed AMA-1 from Plasmodium falciparum FVO clone adsorbed to Alhydrogel(®), the...

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Bibliografiske detaljer
Udgivet i:Malar J
Main Authors: Thera, Mahamadou A., Coulibaly, Drissa, Kone, Abdoulaye K., Guindo, Ando B., Traore, Karim, Sall, Abdourhamane H., Diarra, Issa, Daou, Modibo, Traore, Idrissa M., Tolo, Youssouf, Sissoko, Mady, Niangaly, Amadou, Arama, Charles, Baby, Mounirou, Kouriba, Bourema, Sissoko, Mahamadou S., Sagara, Issaka, Toure, Ousmane B., Dolo, Amagana, Diallo, Dapa A., Remarque, Edmond, Chilengi, Roma, Noor, Ramadhani, Sesay, Sanie, Thomas, Alan, Kocken, Clemens H., Faber, Bart W., Imoukhuede, Egeruan Babatunde, Leroy, Odile, Doumbo, Ogobara K.
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2016
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5006270/
https://ncbi.nlm.nih.gov/pubmed/27577237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12936-016-1466-4
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