The oncometabolite R-2-hydroxyglutarate activates NF-κB-dependent tumor-promoting stromal niche for acute myeloid leukemia cells

Mutations of isocitrate dehydrogenase 1 (IDH1) and IDH2 in acute myeloid leukemia (AML) cells produce the oncometabolite R-2-hydroxyglutarate (R-2HG) to induce epigenetic alteration and block hematopoietic differentiation. However, the effect of R-2HG released by IDH-mutated AML cells on the bone ma...

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Publicado no:Sci Rep
Main Authors: Chen, Jing-Yi, Lai, You-Syuan, Tsai, Hui-Jen, Kuo, Cheng-Chin, Yen, B. Linju, Yeh, Su-Peng, Sun, H. Sunny, Hung, Wen-Chun
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5006242/
https://ncbi.nlm.nih.gov/pubmed/27577048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep32428
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