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Two-pass alignment improves novel splice junction quantification

Motivation: Discovery of novel splicing from RNA sequence data remains a critical and exciting focus of transcriptomics, but reduced alignment power impedes expression quantification of novel splice junctions. Results: Here, we profile performance characteristics of two-pass alignment, which separat...

Полное описание

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Библиографические подробности
Опубликовано в: :Bioinformatics
Главные авторы: Veeneman, Brendan A., Shukla, Sudhanshu, Dhanasekaran, Saravana M., Chinnaiyan, Arul M., Nesvizhskii, Alexey I.
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2016
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5006238/
https://ncbi.nlm.nih.gov/pubmed/26519505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btv642
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