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Common polygenic variation enhances risk prediction for Alzheimer’s disease

The identification of subjects at high risk for Alzheimer’s disease is important for prognosis and early intervention. We investigated the polygenic architecture of Alzheimer’s disease and the accuracy of Alzheimer’s disease prediction models, including and excluding the polygenic component in the m...

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Опубликовано в: :Brain
Главные авторы: Escott-Price, Valentina, Sims, Rebecca, Bannister, Christian, Harold, Denise, Vronskaya, Maria, Majounie, Elisa, Badarinarayan, Nandini, Morgan, Kevin, Passmore, Peter, Holmes, Clive, Powell, John, Brayne, Carol, Gill, Michael, Mead, Simon, Goate, Alison, Cruchaga, Carlos, Lambert, Jean-Charles, van Duijn, Cornelia, Maier, Wolfgang, Ramirez, Alfredo, Holmans, Peter, Jones, Lesley, Hardy, John, Seshadri, Sudha, Schellenberg, Gerard D., Amouyel, Philippe, Williams, Julie
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2015
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5006219/
https://ncbi.nlm.nih.gov/pubmed/26490334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/awv268
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