Valproic Acid and Other HDAC Inhibitors Upregulate FGF21 Gene Expression and Promote Process Elongation in Glia by Inhibiting HDAC2 and 3

BACKGROUND: Fibroblast growth factor 21, a novel regulator of glucose and lipid metabolism, has robust protective properties in neurons. However, its expression and function in glia are unknown. Valproic acid, a mood stabilizer and anticonvulsant, is a histone deacetylase inhibitor and a dynamic gen...

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Veröffentlicht in:Int J Neuropsychopharmacol
Hauptverfasser: Leng, Yan, Wang, Junyu, Wang, Zhifei, Liao, Hsiao-Mei, Wei, Monica, Leeds, Peter, Chuang, De-Maw
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2016
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5006201/
https://ncbi.nlm.nih.gov/pubmed/27207921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ijnp/pyw035
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