BRCA1 and BRCA2 genetic testing—pitfalls and recommendations for managing variants of uncertain clinical significance

BACKGROUND: Increasing use of BRCA1/2 testing for tailoring cancer treatment and extension of testing to tumour tissue for somatic mutation is moving BRCA1/2 mutation screening from a primarily prevention arena delivered by specialist genetic services into mainstream oncology practice. A considerabl...

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Bibliographic Details
Published in:Ann Oncol
Main Authors: Eccles, D. M., Mitchell, G., Monteiro, A. N. A., Schmutzler, R., Couch, F. J., Spurdle, A. B., Gómez-García, E. B.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2015
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Reviews
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5006185/
https://ncbi.nlm.nih.gov/pubmed/26153499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/annonc/mdv278
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