Clinically Applicable Models to Characterize BRCA1 and BRCA2 Variants of Uncertain Significance

PURPOSE: Twenty percent of individuals with a strong family and/or personal history of breast and ovarian cancer carry a deleterious mutation in BRCA1 or BRCA2. Identification of mutations in these genes is extremely beneficial for patients pursuing risk reduction strategies. Approximately 7% of ind...

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Detalhes bibliográficos
Main Authors: Spearman, Andrew D., Sweet, Kevin, Zhou, Xiao-Ping, McLennan, Jane, Couch, Fergus J., Toland, Amanda Ewart
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Clinical Oncology 2008
Assuntos:
Genetic Testing for Cancer
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2651073/
https://ncbi.nlm.nih.gov/pubmed/18824701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2008.17.8228
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