Genetic deletion of TNFα inhibits ultraviolet radiation-induced development of cutaneous squamous cell carcinomas in PKCε transgenic mice via inhibition of cell survival signals

Protein kinase C epsilon (PKCε), a Ca(2+)-independent phospholipid-dependent serine/threonine kinase, is among the six PKC isoforms (α, δ, ε, η, μ, ζ) expressed in both mouse and human skin. Epidermal PKCε level dictates the susceptibility of PKCε transgenic (TG) mice to the development of cutaneous...

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Veröffentlicht in:Carcinogenesis
Hauptverfasser: Singh, Ashok, Singh, Anupama, Bauer, Samuel J., Wheeler, Deric L., Havighurst, Thomas C., Kim, KyungMann, Verma, Ajit K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2016
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5006113/
https://ncbi.nlm.nih.gov/pubmed/26586792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgv162
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