Genetic deletion of TNFα inhibits ultraviolet radiation-induced development of cutaneous squamous cell carcinomas in PKCε transgenic mice via inhibition of cell survival signals

Protein kinase C epsilon (PKCε), a Ca(2+)-independent phospholipid-dependent serine/threonine kinase, is among the six PKC isoforms (α, δ, ε, η, μ, ζ) expressed in both mouse and human skin. Epidermal PKCε level dictates the susceptibility of PKCε transgenic (TG) mice to the development of cutaneous...

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Gepubliceerd in:Carcinogenesis
Hoofdauteurs: Singh, Ashok, Singh, Anupama, Bauer, Samuel J., Wheeler, Deric L., Havighurst, Thomas C., Kim, KyungMann, Verma, Ajit K.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2016
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5006113/
https://ncbi.nlm.nih.gov/pubmed/26586792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgv162
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