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PKCε overexpression, irrespective of genetic background, sensitizes skin to ultraviolet radiation-induced development of squamous cell carcinomas

Chronic exposure to ultraviolet radiation (UVR) is the major etiologic factor in the development of human skin cancers including squamous cell carcinoma (SCC). We have shown that PKCε transgenic mice on FVB/N background, which overexpress PKCε protein approximately 8-fold over endogenous levels in e...

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Bibliografische gegevens
Hoofdauteurs: Sand, Jordan Marshall, Aziz, Moammir Hasan, Dreckschmidt, Nancy Ellen, Havighurst, Thomas, Kim, KyungMann, Verma, Ajit Kumar
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2010
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2794925/
https://ncbi.nlm.nih.gov/pubmed/19626035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jid.2009.212
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