Tissue-specific conditional PKCε knockout mice: a model to precisely reveal PKCε functional role in initiation, promotion and progression of cancer

PKCε is a transforming oncogene and a predictive biomarker of various human cancers. However, a precise in vivo link of PKCε to cancer induction, progression and metastasis remain undefined. To achieve these goals, we generated tissue specific conditional PKCε knockout mice (PKCε-CKO) using cre-lox...

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Publicado en:Oncotarget
Autores principales: Hafeez, Bilal Bin, Meske, Louise, Singh, Ashok, Singh, Anupama, Zhong, Weixiong, Powers, Patricia, John, Manorama, Griep, Anne E., Verma, Ajit K.
Formato: Artigo
Lenguaje:Inglês
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5078076/
https://ncbi.nlm.nih.gov/pubmed/27102301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8850
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