Ataxia telangiectasia-mutated kinase deficiency exacerbates left ventricular dysfunction and remodeling late after myocardial infarction

Ataxia telangiectasia-mutated kinase (ATM), a cell cycle checkpoint protein, is activated in response to DNA damage and oxidative stress. We have previously shown that ATM deficiency is associated with increased apoptosis and fibrosis and attenuation of cardiac dysfunction early (1–7 days) following...

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Detalles Bibliográficos
Publicado en:Am J Physiol Heart Circ Physiol
Autores principales: Daniel, Laura L., Scofield, Stephanie L. C., Thrasher, Patsy, Dalal, Suman, Daniels, Christopher R., Foster, Cerrone R., Singh, Mahipal, Singh, Krishna
Formato: Artigo
Lenguaje:Inglês
Publicado: American Physiological Society 2016
Materias:
Integrative Cardiovascular Physiology and Pathophysiology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5005283/
https://ncbi.nlm.nih.gov/pubmed/27288435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00338.2016
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