Ataxia telangiectasia-mutated kinase deficiency exacerbates left ventricular dysfunction and remodeling late after myocardial infarction

Ataxia telangiectasia-mutated kinase (ATM), a cell cycle checkpoint protein, is activated in response to DNA damage and oxidative stress. We have previously shown that ATM deficiency is associated with increased apoptosis and fibrosis and attenuation of cardiac dysfunction early (1–7 days) following...

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Pubblicato in:Am J Physiol Heart Circ Physiol
Autori principali: Daniel, Laura L., Scofield, Stephanie L. C., Thrasher, Patsy, Dalal, Suman, Daniels, Christopher R., Foster, Cerrone R., Singh, Mahipal, Singh, Krishna
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2016
Soggetti:
Integrative Cardiovascular Physiology and Pathophysiology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5005283/
https://ncbi.nlm.nih.gov/pubmed/27288435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00338.2016
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