Exogenous ubiquitin modulates chronic β-adrenergic receptor-stimulated myocardial remodeling: role in Akt activity and matrix metalloproteinase expression

β-Adrenergic receptor (β-AR) stimulation increases extracellular ubiquitin (UB) levels, and extracellular UB inhibits β-AR-stimulated apoptosis in adult cardiac myocytes. This study investigates the role of exogenous UB in chronic β-AR-stimulated myocardial remodeling. l-Isoproterenol (ISO; 400 μg·k...

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Detalhes bibliográficos
Main Authors: Daniels, Christopher R., Foster, Cerrone R., Yakoob, Sana, Dalal, Suman, Joyner, William L., Singh, Mahipal, Singh, Krishna
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2012
Assuntos:
Integrative Cardiovascular Physiology and Pathophysiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3532534/
https://ncbi.nlm.nih.gov/pubmed/23042947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00401.2012
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