Serine 421 regulates mutant huntingtin toxicity and clearance in mice

Huntington’s disease (HD) is a progressive, adult-onset neurodegenerative disease caused by a polyglutamine (polyQ) expansion in the N-terminal region of the protein huntingtin (HTT). There are no cures or disease-modifying therapies for HD. HTT has a highly conserved Akt phosphorylation site at ser...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Kratter, Ian H., Zahed, Hengameh, Lau, Alice, Tsvetkov, Andrey S., Daub, Aaron C., Weiberth, Kurt F., Gu, Xiaofeng, Saudou, Frédéric, Humbert, Sandrine, Yang, X. William, Osmand, Alex, Steffan, Joan S., Masliah, Eliezer, Finkbeiner, Steven
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5004962/
https://ncbi.nlm.nih.gov/pubmed/27525439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI80339
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