Mechanistically distinct cancer-associated mTOR activation clusters predict sensitivity to rapamycin

Genomic studies have linked mTORC1 pathway–activating mutations with exceptional response to treatment with allosteric inhibitors of mTORC1 called rapalogs. Rapalogs are approved for selected cancer types, including kidney and breast cancers. Here, we used sequencing data from 22 human kidney cancer...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Xu, Jianing, Pham, Can G., Albanese, Steven K., Dong, Yiyu, Oyama, Toshinao, Lee, Chung-Han, Rodrik-Outmezguine, Vanessa, Yao, Zhan, Han, Song, Chen, David, Parton, Daniel L., Chodera, John D., Rosen, Neal, Cheng, Emily H., Hsieh, James J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5004947/
https://ncbi.nlm.nih.gov/pubmed/27482884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI86120
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados