Local TNF causes NFATc1-dependent cholesterol-mediated podocyte injury

High levels of circulating TNF and its receptors, TNFR1 and TNFR2, predict the progression of diabetic kidney disease (DKD), but their contribution to organ damage in DKD remains largely unknown. Here, we investigated the function of local and systemic TNF in podocyte injury. We cultured human podoc...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Pedigo, Christopher E., Ducasa, Gloria Michelle, Leclercq, Farah, Sloan, Alexis, Mitrofanova, Alla, Hashmi, Tahreem, Molina-David, Judith, Ge, Mengyuan, Lassenius, Mariann I., Forsblom, Carol, Lehto, Markku, Groop, Per-Henrik, Kretzler, Matthias, Eddy, Sean, Martini, Sebastian, Reich, Heather, Wahl, Patricia, Ghiggeri, GianMarco, Faul, Christian, Burke, George W., Kretz, Oliver, Huber, Tobias B., Mendez, Armando J., Merscher, Sandra, Fornoni, Alessia
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5004940/
https://ncbi.nlm.nih.gov/pubmed/27482889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI85939
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