Cyclin-dependent kinase 2 protects podocytes from apoptosis

Loss of podocytes is an early feature of diabetic nephropathy (DN) and predicts its progression. We found that treatment of podocytes with sera from normoalbuminuric type 1 diabetes patients with high lipopolysaccharide (LPS) activity, known to predict progression of DN, downregulated CDK2 (cyclin-d...

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Udgivet i:Sci Rep
Main Authors: Saurus, Pauliina, Kuusela, Sara, Dumont, Vincent, Lehtonen, Eero, Fogarty, Christopher L., Lassenius, Mariann I., Forsblom, Carol, Lehto, Markku, Saleem, Moin A., Groop, Per-Henrik, Lehtonen, Sanna
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4753499/
https://ncbi.nlm.nih.gov/pubmed/26876672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep21664
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