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Local TNF causes NFATc1-dependent cholesterol-mediated podocyte injury

High levels of circulating TNF and its receptors, TNFR1 and TNFR2, predict the progression of diabetic kidney disease (DKD), but their contribution to organ damage in DKD remains largely unknown. Here, we investigated the function of local and systemic TNF in podocyte injury. We cultured human podoc...

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書目詳細資料
發表在:J Clin Invest
Main Authors: Pedigo, Christopher E., Ducasa, Gloria Michelle, Leclercq, Farah, Sloan, Alexis, Mitrofanova, Alla, Hashmi, Tahreem, Molina-David, Judith, Ge, Mengyuan, Lassenius, Mariann I., Forsblom, Carol, Lehto, Markku, Groop, Per-Henrik, Kretzler, Matthias, Eddy, Sean, Martini, Sebastian, Reich, Heather, Wahl, Patricia, Ghiggeri, GianMarco, Faul, Christian, Burke, George W., Kretz, Oliver, Huber, Tobias B., Mendez, Armando J., Merscher, Sandra, Fornoni, Alessia
格式: Artigo
語言:Inglês
出版: American Society for Clinical Investigation 2016
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5004940/
https://ncbi.nlm.nih.gov/pubmed/27482889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI85939
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