Functional analysis of AEBP2, a PRC2 Polycomb protein, reveals a Trithorax phenotype in embryonic development and in ESCs

The Polycomb repressive complexes PRC1 and PRC2 are key mediators of heritable gene silencing in multicellular organisms. Here, we characterise AEBP2, a known PRC2 co-factor which, in vitro, has been shown to stimulate PRC2 activity. We show that AEBP2 localises specifically to PRC2 target loci, inc...

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Bibliographic Details
Published in:Development
Main Authors: Grijzenhout, Anne, Godwin, Jonathan, Koseki, Haruhiko, Gdula, Michal Ryszard, Szumska, Dorota, McGouran, Joanna F., Bhattacharya, Shoumo, Kessler, Benedikt M., Brockdorff, Neil, Cooper, Sarah
Format: Artigo
Language:Inglês
Published: The Company of Biologists Ltd 2016
Subjects:
Stem Cells and Regeneration
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5004903/
https://ncbi.nlm.nih.gov/pubmed/27317809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.123935
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