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AβPP processing results in greater toxicity per amount of Aβ(1-42) than individually expressed and secreted Aβ(1-42) in Drosophila melanogaster

The aggregation of the amyloid-β (Aβ) peptide into fibrillar deposits has long been considered the key neuropathological hallmark of Alzheimer's disease (AD). Aβ peptides are generated from proteolytic processing of the transmembrane Aβ precursor protein (AβPP) via sequential proteolysis throug...

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Publicat a:Biol Open
Autors principals: Bergkvist, Liza, Sandin, Linnea, Kågedal, Katarina, Brorsson, Ann-Christin
Format: Artigo
Idioma:Inglês
Publicat: The Company of Biologists Ltd 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5004604/
https://ncbi.nlm.nih.gov/pubmed/27387531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/bio.017194
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