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AβPP processing results in greater toxicity per amount of Aβ(1-42) than individually expressed and secreted Aβ(1-42) in Drosophila melanogaster

The aggregation of the amyloid-β (Aβ) peptide into fibrillar deposits has long been considered the key neuropathological hallmark of Alzheimer's disease (AD). Aβ peptides are generated from proteolytic processing of the transmembrane Aβ precursor protein (AβPP) via sequential proteolysis throug...

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Bibliografiske detaljer
Udgivet i:Biol Open
Main Authors: Bergkvist, Liza, Sandin, Linnea, Kågedal, Katarina, Brorsson, Ann-Christin
Format: Artigo
Sprog:Inglês
Udgivet: The Company of Biologists Ltd 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5004604/
https://ncbi.nlm.nih.gov/pubmed/27387531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/bio.017194
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