Forced co-expression of IL-21 and IL-7 in whole-cell cancer vaccines promotes antitumor immunity

Genetic modification of whole-cell cancer vaccines to augment their efficacies has a history of over two and a half decades. Various genes and gene combinations, targeting different aspects of immune responses have been tested in pursuit of potent adjuvant effects. Here we show that co-expression of...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Gu, Yang-Zhuo, Fan, Chuan-Wen, Lu, Ran, Shao, Bin, Sang, Ya-Xiong, Huang, Qiao-Rong, Li, Xue, Meng, Wen-Tong, Mo, Xian-Ming, Wei, Yu-Quan
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5004106/
https://ncbi.nlm.nih.gov/pubmed/27571893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep32351
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