Cell-extrinsic MHC class I molecule engagement augments human NK cell education programmed by cell-intrinsic MHC class I

The effector potential of NK cells is counterbalanced by their sensitivity to inhibition by “self” MHC class I molecules in a process called “education”. In humans, interactions between inhibitory killer immunoglobulin-like receptors (KIR) and human MHC (HLA) mediate NK cell education. In HLA-B* 27:...

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Vydáno v:Immunity
Hlavní autoři: Boudreau, Jeanette E., Liu, Xiao-Rong, Zhao, Zeguo, Zhang, Aaron, Shultz, Leonard D., Greiner, Dale L., Dupont, Bo, Hsu, Katharine C.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5003427/
https://ncbi.nlm.nih.gov/pubmed/27496730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2016.07.005
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