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Coiled-coil destabilizing residues in the group A Streptococcus M1 protein are required for functional interaction

The sequences of M proteins, the major surface-associated virulence factors of the widespread bacterial pathogen group A Streptococcus, are antigenically variable but have in common a strong propensity to form coiled coils. Paradoxically, these sequences are also replete with coiled-coil destabilizi...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Stewart, Chelsea M., Buffalo, Cosmo Z., Valderrama, J. Andrés, Henningham, Anna, Cole, Jason N., Nizet, Victor, Ghosh, Partho
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2016
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5003295/
https://ncbi.nlm.nih.gov/pubmed/27512043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1606160113
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