Coiled-Coil Irregularities and Instabilities in Group A Streptococcus M1 Are Required for Virulence

Antigenically variable M proteins are major virulence factors and immunogens of the human pathogen group A Streptococcus (GAS). Here, we report the ∼3 angstrom resolution structure of a GAS M1 fragment containing the regions responsible for eliciting type-specific, protective immunity and for bindin...

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Main Authors: McNamara, Case, Zinkernagel, Annelies S., Macheboeuf, Pauline, Cunningham, Madeleine W., Nizet, Victor, Ghosh, Partho
Format: Artigo
Sprog:Inglês
Udgivet: 2008
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2288698/
https://ncbi.nlm.nih.gov/pubmed/18323455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1154470
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