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Coiled-Coil Irregularities and Instabilities in Group A Streptococcus M1 Are Required for Virulence
Antigenically variable M proteins are major virulence factors and immunogens of the human pathogen group A Streptococcus (GAS). Here, we report the ∼3 angstrom resolution structure of a GAS M1 fragment containing the regions responsible for eliciting type-specific, protective immunity and for bindin...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2288698/ https://ncbi.nlm.nih.gov/pubmed/18323455 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1154470 |
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