Crystal structure of a human neuronal nAChR extracellular domain in pentameric assembly: Ligand-bound α2 homopentamer

In this study we report the X-ray crystal structure of the extracellular domain (ECD) of the human neuronal α2 nicotinic acetylcholine receptor (nAChR) subunit in complex with the agonist epibatidine at 3.2 Å. Interestingly, α2 was crystallized as a pentamer, revealing the intersubunit interactions...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Kouvatsos, Nikolaos, Giastas, Petros, Chroni-Tzartou, Dafni, Poulopoulou, Cornelia, Tzartos, Socrates J.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2016
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5003238/
https://ncbi.nlm.nih.gov/pubmed/27493220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1602619113
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