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Crizotinib resistance: implications for therapeutic strategies
In 2007, a chromosomal rearrangement resulting in a gene fusion leading to expression of a constitutively active anaplastic lymphoma kinase (ALK) fusion protein was identified as an oncogenic driver in non-small-cell lung cancer (NSCLC). ALK rearrangements are detected in 3%–7% of patients with NSCL...
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| Published in: | Ann Oncol |
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| Main Authors: | , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Oxford University Press
2016
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5003168/ https://ncbi.nlm.nih.gov/pubmed/27573756 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/annonc/mdw305 |
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