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Early Phase Studies of Biomarkers: What Target Sensitivity and Specificity Values Might Confer Clinical Utility?

BACKGROUND: Many cancer biomarker research studies seek to develop markers that can accurately detect or predict future onset of disease. To design and evaluate these studies one must specify the levels of accuracy sought. However, justified target levels are rarely available. METHODS: We describe a...

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Vydáno v:Clin Chem
Hlavní autoři: Pepe, Margaret S., Janes, Holly, Li, Christopher I., Bossuyt, Patrick M., Feng, Ziding, Hilden, Jørgen
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5003106/
https://ncbi.nlm.nih.gov/pubmed/27001493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1373/clinchem.2015.252163
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