Hyperinsulinemia augments endothelin‐1 protein expression and impairs vasodilation of human skeletal muscle arterioles

Hyperinsulinemia is a hallmark of insulin resistance‐associated metabolic disorders. Under physiological conditions, insulin maintains a balance between nitric oxide (NO) and, the potent vasoconstrictor, endothelin‐1 (ET‐1). We tested the hypothesis that acute hyperinsulinemia will preferentially au...

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Detalhes bibliográficos
Publicado no:Physiol Rep
Main Authors: Mahmoud, Abeer M., Szczurek, Mary R., Blackburn, Brian K., Mey, Jacob T., Chen, Zhenlong, Robinson, Austin T., Bian, Jing‐Tan, Unterman, Terry G., Minshall, Richard D., Brown, Michael D., Kirwan, John P., Phillips, Shane A., Haus, Jacob M.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5002909/
https://ncbi.nlm.nih.gov/pubmed/27796268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14814/phy2.12895
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