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Role of tau in the spatial organization of axonal microtubules: keeping parallel microtubules evenly distributed despite macromolecular crowding

Opposing views have been proposed regarding the role of tau, the principal microtubule-associated protein in axons. On the one hand, tau forms cross-bridges at the interface between microtubules and induces microtubule bundling in neurons. On the other hand, tau is also considered a polymer brush wh...

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Detalhes bibliográficos
Publicado no:Cell Mol Life Sci
Main Authors: Méphon-Gaspard, Alix, Boca, Mirela, Pioche-Durieu, Catherine, Desforges, Bénédicte, Burgo, Andrea, Hamon, Loic, Piétrement, Olivier, Pastré, David
Formato: Artigo
Idioma:Inglês
Publicado em: Springer International Publishing 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5002045/
https://ncbi.nlm.nih.gov/pubmed/27076215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-016-2216-z
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