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Free mRNA in excess upon polysome dissociation is a scaffold for protein multimerization to form stress granules
The sequence of events leading to stress granule assembly in stressed cells remains elusive. We show here, using isotope labeling and ion microprobe, that proportionally more RNA than proteins are present in stress granules than in surrounding cytoplasm. We further demonstrate that the delivery of s...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4117795/ https://ncbi.nlm.nih.gov/pubmed/25013173 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku582 |
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