Free mRNA in excess upon polysome dissociation is a scaffold for protein multimerization to form stress granules

The sequence of events leading to stress granule assembly in stressed cells remains elusive. We show here, using isotope labeling and ion microprobe, that proportionally more RNA than proteins are present in stress granules than in surrounding cytoplasm. We further demonstrate that the delivery of s...

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Hlavní autoři: Bounedjah, Ouissame, Desforges, Bénédicte, Wu, Ting-Di, Pioche-Durieu, Catherine, Marco, Sergio, Hamon, Loic, Curmi, Patrick A., Guerquin-Kern, Jean-Luc, Piétrement, Olivier, Pastré, David
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2014
Témata:
RNA
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4117795/
https://ncbi.nlm.nih.gov/pubmed/25013173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku582
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