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Mice expressing low levels of CalDAG-GEFI exhibit markedly impaired platelet activation with minor impact on hemostasis

OBJECTIVE: The tight regulation of platelet adhesiveness, mediated by the αIIbβ3 integrin, is critical for hemostasis and prevention of thrombosis. We recently demonstrated that integrin affinity in platelets is controlled by the guanine nucleotide exchange factor, CalDAG-GEFI (CD-GEFI), and its tar...

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Vydáno v:Arterioscler Thromb Vasc Biol
Hlavní autoři: Piatt, Raymond, Paul, David S., Lee, Robert H., McKenzie, Steven E., Parise, Leslie V., Cowley, Dale O., Cooley, Brian C., Bergmeier, Wolfgang
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5001889/
https://ncbi.nlm.nih.gov/pubmed/27417588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.116.307874
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