Multikinase inhibitor regorafenib inhibits the growth and metastasis of colon cancer with abundant stroma

Interaction between tumor cells and stromal cells plays an important role in the growth and metastasis of colon cancer. We previously found that carcinoma‐associated fibroblasts (CAFs) expressed platelet‐derived growth factor receptor‐β (PDGFR‐β) and that PDGFR targeted therapy using imatinib or nil...

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Veröffentlicht in:Cancer Sci
Hauptverfasser: Takigawa, Hidehiko, Kitadai, Yasuhiko, Shinagawa, Kei, Yuge, Ryo, Higashi, Yukihito, Tanaka, Shinji, Yasui, Wataru, Chayama, Kazuaki
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2016
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Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5001714/
https://ncbi.nlm.nih.gov/pubmed/26865419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.12907
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