Retinol Promotes In Vitro Growth of Proximal Colon Organoids through a Retinoic Acid-Independent Mechanism

Retinol (ROL), the alcohol form of vitamin A, is known to control cell fate decision of various types of stem cells in the form of its active metabolite, retinoic acid (RA). However, little is known about whether ROL has regulatory effects on colonic stem cells. We examined in this study the effect...

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Veröffentlicht in:PLoS One
Hauptverfasser: Matsumoto, Taichi, Mochizuki, Wakana, Nibe, Yoichi, Akiyama, Shintaro, Matsumoto, Yuka, Nozaki, Kengo, Fukuda, Masayoshi, Hayashi, Ayumi, Mizutani, Tomohiro, Oshima, Shigeru, Watanabe, Mamoru, Nakamura, Tetsuya
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2016
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5001647/
https://ncbi.nlm.nih.gov/pubmed/27564706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0162049
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