Tetraspanin-2 promotes glucotoxic apoptosis by regulating the JNK/β-catenin signaling pathway in human pancreatic β cells

Diabetes mellitus is a complex and heterogeneous disease, which has β-cell dysfunction at its core. Glucotoxicity affects pancreatic islets, causing β-cell apoptosis. However, the role of JNK/β-catenin signaling in glucotoxic β-cell apoptosis is not well understood. Recently, we identified tetraspan...

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Detalhes bibliográficos
Publicado no:FASEB J
Main Authors: Hwang, In-Hu, Park, Junsoo, Kim, Jung Min, Kim, Seung Il, Choi, Jong-Soon, Lee, Kyung-Bok, Yun, Sung Ho, Lee, Min-Goo, Park, Soo Jung, Jang, Ik-Soon
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5001516/
https://ncbi.nlm.nih.gov/pubmed/27247127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201600240RR
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