Inhibition of ER stress and unfolding protein response pathways causes skeletal muscle wasting during cancer cachexia

Cachexia is a devastating syndrome that causes morbidity and mortality in a large number of patients with cancer. However, the mechanisms of cancer cachexia remain poorly understood. Accumulation of misfolded proteins in the endoplasmic reticulum (ER) causes stress. The ER responds to this stress th...

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Detalhes bibliográficos
Publicado no:FASEB J
Main Authors: Bohnert, Kyle R., Gallot, Yann S., Sato, Shuichi, Xiong, Guangyan, Hindi, Sajedah M., Kumar, Ashok
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5001510/
https://ncbi.nlm.nih.gov/pubmed/27206451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201600250RR
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