CHAI and LATAIE: new genetic diseases of CTLA-4 checkpoint insufficiency

CTLA-4 is a critical inhibitory “checkpoint” molecule of immune activation. Several recent reports have described patients with immune dysregulation and lymphoproliferative disease resulting from 2 different genetic diseases that directly or indirectly cause CTLA-4 deficiency. Numerous articles have...

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Dades bibliogràfiques
Publicat a:Blood
Autors principals: Lo, Bernice, Fritz, Jill M., Su, Helen C., Uzel, Gulbu, Jordan, Michael B., Lenardo, Michael J.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2016
Matèries:
BLOOD Spotlight
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5000841/
https://ncbi.nlm.nih.gov/pubmed/27418640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-04-712612
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