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CHAI and LATAIE: new genetic diseases of CTLA-4 checkpoint insufficiency
CTLA-4 is a critical inhibitory “checkpoint” molecule of immune activation. Several recent reports have described patients with immune dysregulation and lymphoproliferative disease resulting from 2 different genetic diseases that directly or indirectly cause CTLA-4 deficiency. Numerous articles have...
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| Опубликовано в: : | Blood |
|---|---|
| Главные авторы: | , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society of Hematology
2016
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5000841/ https://ncbi.nlm.nih.gov/pubmed/27418640 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-04-712612 |
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