Inhibitory Effect of 2,3,5,6-Tetrafluoro-4-[4-(aryl)-1H-1,2,3-triazol-1-yl]benzenesulfonamide Derivatives on HIV Reverse Transcriptase Associated RNase H Activities

The HIV-1 ribonuclease H (RNase H) function of the reverse transcriptase (RT) enzyme catalyzes the selective hydrolysis of the RNA strand of the RNA:DNA heteroduplex replication intermediate, and represents a suitable target for drug development. A particularly attractive approach is constituted by...

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Bibliographic Details
Published in:Int J Mol Sci
Main Authors: Pala, Nicolino, Esposito, Francesca, Rogolino, Dominga, Carcelli, Mauro, Sanna, Vanna, Palomba, Michele, Naesens, Lieve, Corona, Angela, Grandi, Nicole, Tramontano, Enzo, Sechi, Mario
Format: Artigo
Language:Inglês
Published: MDPI 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5000766/
https://ncbi.nlm.nih.gov/pubmed/27556447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms17081371
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