NHX-5, an Endosomal Na(+)/H(+) Exchanger, Is Associated with Metformin Action

Diabetes is one of the most impactful diseases worldwide. The most commonly prescribed anti-diabetic drug is metformin. In this study, we identified an endosomal Na(+)/H(+) exchanger (NHE) as a new potential target of metformin from an unbiased screen in Caenorhabditis elegans. The same NHE homolog...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Kim, Jeongho, Lee, Hye-Yeon, Ahn, Jheesoo, Hyun, Moonjung, Lee, Inhwan, Min, Kyung-Jin, You, Young-Jai
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2016
Schlagworte:
Accelerated Communications
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5000102/
https://ncbi.nlm.nih.gov/pubmed/27435670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C116.744037
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