NHX-5, an Endosomal Na(+)/H(+) Exchanger, Is Associated with Metformin Action

Diabetes is one of the most impactful diseases worldwide. The most commonly prescribed anti-diabetic drug is metformin. In this study, we identified an endosomal Na(+)/H(+) exchanger (NHE) as a new potential target of metformin from an unbiased screen in Caenorhabditis elegans. The same NHE homolog...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Biol Chem
Prif Awduron: Kim, Jeongho, Lee, Hye-Yeon, Ahn, Jheesoo, Hyun, Moonjung, Lee, Inhwan, Min, Kyung-Jin, You, Young-Jai
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2016
Pynciau:
Accelerated Communications
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5000102/
https://ncbi.nlm.nih.gov/pubmed/27435670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C116.744037
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg